- PRC mimics wild clot and has natural fibrous micro-structure
- PRP harvest and chemical coagulation techniques result in monolithic artificial gels or fragile liquids with no natural counterpart
- ClotMaster PRC is 100% autologous
- No Centrifuge, device activated
- PRC forms into structural, sutureable materials
- Both injected as a liquid or filler, only PRC has unique “twine” structure to resist migration and compression
- PRC can deliver cells or other materials and keep its shape
- PRC has an open structure to accommodate cell ingrowth or delivery
- Thrombin activation of platelets reduces factor release at 7 days vs. mechanical activation
Only ClotMaster Offers Platelet Rich Clot
A controlled fibrin scaffold formation with higher platelet capture and more sustained release growth factors than PRP, which can be used alone or in combination with other biomaterials, implants, grafts, and cells…such as stem cells from fat and marrow
Enhanced healing through application of bioactive factors, especially for biologically compromised tissue, is appealing for orthopedic surgeons around the world. After all, there is a clear clinical need and much enthusiasm for the application of concentrated platelets, which release a large quantity of growth factors to encourage recovery in non-healing injuries or surgical sites. However, the matrix form and structure has a profound effect upon what type of tissue stem cells become. Porosity, orientation of fibers and density of the scaffold all contribute to stem cell fate of final form and function.
In the past, the focus was on using Platelet Rich Plasma (PRP) as a way of delivering increased concentrations of autologous growth factors in an effort to biologically augment tissue healing. However, PSC believes PRP has several shortcomings including cost and variable production methods. In addition, liquid PRP disseminates upon surgical application and is an inefficient short-term delivery mechanism that does not entail a long-term contact with the surgery site.
An alternative method to PRP is to create an exogenous fibrin blood clot scaffold containing platelets or Platelet Rich Clot (PRC), as well as platelet derived and other bioactive components.
Immuno-histochemical staining of these fibrin networks has demonstrated “nests” of platelets that become trapped within the fibrin scaffold and cytokines bind to fibrin so the fibrin scaffold becomes a growth factor reservoir that may allow growth factor release slowly over days. Exogenous fibrin blood clot can act as a stable mechanism for long-term direct delivery of growth factors and as a three dimensional native scaffold for cell adhesion and proliferation.